Cpds. of formula (I) and their acid addn. salts: (where Z is opt. substd. alkylene or monounsatd. alkenylene; both opt. interrupted by is not 2 heteroatoms and both with 4-7 chain members, or Z is opt. substd. diunsatd. alkenylene, opt. interrupted by is not 2 N atoms and contg. 4-6 chain members; and R is alkyl, CF3, alkoxy, halo or H), have antibacterial and antiparasitic action, esp. action against plasmodia (e.g. Plasmodium berghei). They may be used therapeutically or prophylactically) against normal- and chloroquin-resistant strains of malaria. (I) also have blood-pressure decreasing and diuretic activity and are inters. for other materials, esp. pharmaceuticals.
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