PROCESS FOR PREPARING 1,2-BENZISOTHIAZOLIN-3-ONA WITH ANTI-THROMBOTIC EFFECT,APPLICATION OF SAME FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS WITH ANTI-THROMBIC EFFECT AND APPLICATION OF THESE PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF THROMBOSIS

摘要

6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative embodiment, can be prepared by cyclization of an appropriately substituted bis-[2-(aminoalkylcarbamyl)phenyl]disulfide, or by other disclosed methods.