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摘要

The Specification describes compounds of the general formula WHEREIN X represents a hydrogen, chlorine or fluorine atom; R1 represents a beta -hydroxy group, an oxo group or (when X is a chlorine atom) a beta -chlorine atom; R2 represents a hydrogen atom, a methylene group or an alpha - or beta -methyl group; R3 represents a hydrogen atom or C1-4alkyl or phenyl group; R4 represents a methyl group substituted by at least one halogen atom; an ethyl group substituted by at least one fluorine and/or iodine atom; or a propyl group substituted by at least one halogen atom; and represents a single or double bond. The Specification also describes processes for the preparation of compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I have good anti-inflammatory activity, particularly on topical application.