process for the preparation of pharmaceutical preparations, thus formed preparations and a method for the preparation of cephalosporin derivatives for use in these preparations.

摘要

1463999 Cephalosporin derivatives TAKEDA YAKUHIN KOGYO KK 19 Dec 1974 [20 Dec 1973] 54952/74 Heading C2C Novel compounds I (in which RSP1/SP is acyl and RSP2/SP is alkylene optionally substituted by 1-6C alkoxy) and salts thereof are prepared by reacting a lactol of Formula II or an alkyl or acyl derivative thereof with a compound III or a salt thereof or by acylation of a compound IV Compounds II may be prepared by cyclization of compounds V using a hexavalent chromium compound. The compounds V may be prepared by reaction of the corresponding 3-acetoxymethyl cephem compound with lipase. Pharmaceutical compositions useful as antibiotics comprise a compound I together with a suitable excipient.