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PROCESS FOR PREPARING 9*100DIHYDROERGOCINE AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITIVES THEREOF AND APPLICATION AS MEDICINE
PROCESS FOR PREPARING 9*100DIHYDROERGOCINE AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITIVES THEREOF AND APPLICATION AS MEDICINE
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机译:制备9 * 100二氢古丁酸及其生理可接受的酸添加剂的方法及其在医学中的应用
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摘要
(I) and its acid addn. salts are prepd. by hydrogenation of ergosine in dimethylformamide with shaking, at normal press., in the dark using a 10% Pd/C catalyst and opt. converting (I) to its salts. (I) is used to treat arterial hypertension, peripheral angiopathy, cerebral circulatory troubles, cardiac arrythmia and migraine. It is administered parenterally or enterally in daily doses of 0.3-10 7g/70 kg Acute toxicity (methanesulphonate i.p. in mice LD50=72.2 mg/kg, i.p. in rats=N400mg/kg) and pharmacological tests (arterial press., effect on heart, antiadrenaline effect, antiserotonin effect) are described. The reaction is effected rapidly reducing by-prods. due to degradation and giving high yields of (I).
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