PULMONARY SURFACTANT TAA546* ITS PREPARATION* AND REMEDY FOR PULMONARY HYALINE MEMBRANE SYNDROME COMPRISING IT AS ACTIVE CONSTITUENT

摘要

PURPOSE:The title substance, effective against apneumatosis or atelectasis of a neonate, and comprising specific amounts of a phospholipid, a neutral fat, tge total cholesterol, a hydrocarbon and a protein, present in a lung tissue of a mammal. CONSTITUTION:A pulmonary surfactant TA-546 comprising 75.0-95.5wt% a phospholipid, 1.8-14.0wt% a neutral fat, 3.0wt% or less the total cholesterol, 0.1-1.5wt% a hydrocarbon and 5.0wt% or less a protein, each being present in a lung tissue of a mammal, e.g. cattle, horse, sheep or hog. The surfactant has a dramatic effect on atelectasis which will cause a respiratory distrss syndrome or pulmonary hyaline membrane in the first rank of the cause of death of an immature infant, and can be mass-produced as a sterile product by extracting a lung fragment of a mammal.