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PROCESS FOR PREPARING DERIVATIVES OF TRANS-2-SUBSTITUTED-5-ARYLO-2,3,4,4A,5,9B-HEXAHYDRO-1H-PYRIDO/4,3-B/INDOLE RIL-2,3,4,4A,5,9B-GEKSAGIDRO-1H-PIRIDO/4,3-B/INDOLA
PROCESS FOR PREPARING DERIVATIVES OF TRANS-2-SUBSTITUTED-5-ARYLO-2,3,4,4A,5,9B-HEXAHYDRO-1H-PYRIDO/4,3-B/INDOLE RIL-2,3,4,4A,5,9B-GEKSAGIDRO-1H-PIRIDO/4,3-B/INDOLA
2-Substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles of the formula (I): IMAGE and the pharmaceutically-acceptable salts thereof, wherein the hydrogen atoms in the 4a position and 9b positions are in a trans relationship to each other and the 5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole moiety is dextrorotatory; X1 and Y1 are the same or different and are each hydrogen or fluoro; Z1 is hydrogen, fluoro or methoxy; M is a member selected from the group consisting of IMAGE a mixture thereof and C=O and n is 3 or 4; their use as tranquilizing agents, pharmaceutical compositions containing them and a process for their production.
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机译:式(I)的2-取代的5-芳基-2,3,4,4a,5,9b-六氢-1H-吡啶并[4,3-b]吲哚:及其药学上可接受的盐,其中4a位和9b位的氢原子彼此成反式关系,而5-芳基-2,3,4,4a,5,9b-六氢-1H-吡啶基[4,3-b]吲哚部分是右旋的; X 1和Y 1相同或不同,分别为氢或氟。 Z1是氢,氟或甲氧基; M为选自由及其C = O的混合物组成的组中的成员,且n为3或4;它们作为稳定剂的用途,含有它们的药物组合物及其生产方法。
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