new 17 (20) - omettade 20 isonitril - steroidderivat, seen for framstellning and anvendning derav at framstellning of 17alfa - hydroxy - 20 - keto steroids

摘要

Novel 20-isocyano- DELTA 17(20)-steroids of the formula IMAGE I wherein R1 is selected from the group consisting of (1) hydrogen, (2) alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, an oxygen function and a nitrogen function and (3) alkenyl and alkynyl of 2 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms, Alk1, is alkyl of 1 to 8 carbon atoms and the A,B,C, and D rings may contain one or more double bonds and may be optionally substituted with at least one member of the group consisting of -OH, =0, halogens, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms and a process for their preparation and their use to prepare 17 alpha -ol-20-keto steroids.