TANDEM QUADRUPOLE MASS SPECTROMETER FOR SELECTED ION FRAGMENTATION STUDIES AND LOW ENERGY COLLISION INDUCED DISSOCIATOR THEREFOR

摘要

TANDEM QUADRUPOLE MASS SPECTROMETER FOR SELECTEDION FRAGMENTATION STUDIES AND LOW ENERGY COLLISIONINDUCED DISSOCIATOR THEREFORInventors:CHRISTIE GEORGE ENKERICHARD ALAN YOSTJAMES D. MORRISONAbstract of the DisclosureA tandem quadrupole-based mass spectrometer in-cluding a highly efficient intermediate fragmentationstage. The disclosed fragmentation stage employs collision-induced dissociation (CID) in an electrodynamic focus device,which may be a quadrupole operated in a broad band filtermode. The disclosed CID process occurs at low energy (e.g.,less than 1 keV, but preferably 2 eV to 100 eV), and isquite different from the high energy (e.g., greater than 1keV, and typically 3 keV to 10 keV) CID process in priortandem instruments such as mass-analyzed ion kinetic energyspectrometry (MIKES) systems. The efficiency of the presentCID fragmentation is as high as 65%.Research CorporationProject No. 039-1197Corresponding to U.S.Application Serial No.960,439 filed November 13, 1978