Non-steroidal antiinflammatory agents - for treatment of micro:vascular disease, e.g. diabetic retinopathy or diabetic nephropathy

摘要

The use of 6-methoxy-alpha-methyl-2- naphthaleneacetic acid; alpha-methyl-4-(2-methylpropyl) benzeneacetic acid; 2-(4-isopropylphenyl)propionic acid; alpha-methyl-3-phenoxybenzeneacetic acid; 3-benzoyl-alpha- methylbenzeneacetic acid; 2-fluoro-alpha- methyl (1,1'-diphenyl)-4-acetic acid; 4-(1,3-dihydro-1-oxo-2H- isoindol-2-yl)- alpha-methylbenzeneacetic acid; 2-(2,6- dichlorophenylomino) benzeneacetic acid; rac-2-(4-chlorophenyl) -alpha- methyl-5-benzoxozoleacetic acid; 5-(4-chlorobenzoyl)-1,4- dimethyl- 1H-pyrrole-2-acetic acid; gamma-oxo-(1,1'-biphenyl)- 4- butyric acid; 2-(2,4-dichlorophenoxy)benzeneocetic acid; 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- 1H-indole-3-acetic acid; 4,5-diphenyl-2-oxozolepropionic acid; 4-hydroxy-2-methyl-N- (2-pyridyl)- 2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; 3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)- alpha-methylbenzeneacetic acid; 7-methyl-1-methylene-4-phenyl- 2(1H)-quinazolinone; 5-fluoro-2-methyl- 1-(4-methylsulphinyl-phenyl)methylene)- 1H- indene-3-acetic acid; 1-methyl-5-(4-methylbenzoyl)- 1H-pyrrole-2- acetic acid; 4-(2-methylpropyl)venzeneacetic 4-(2-methylpropyl)benzeneacetic acid; ; 1-(p-chlorobenzoyl)-5- methoxy- 2-methylindole-3-acetic acid ester with glycollic acid; rac-6-chloro-alpha-methyl- 9H-carbazole-2-acetic acid; 1-cinnamoyl-5-methoxy- 2-methylindole-3-acetic acid; alpha-methyl- 9H-fluorene-2-acetic acid; 3-chloro-alpha-methyl-4- (2-thienylcarbonyl)benzeneacetic acid; 1-(4-chlorophenyl)-2,5- dimethyl- 1H-pyrrol-3-acetic acid; 1-(4-azidobenzoyl)-5-methoxy- 2-methyl-1H-indole- 3-acetic acid etc. and their pharmaceutically acceptable salts in improving or preventing microvascular diseases in humans and other mammals is new. Used for treatment of microvascular diseases, esp. those of the skin, kidneys and retina resulting from complications of diabetes mellitus, e.g. diabetic retinopathy or diabetic nephropathy.