CORPUS LUTEUM CONTRACTOR OR UTEROTONIC AGENT CONTAINING PROSTAGLANDIN F2 ANALOG

摘要

PURPOSE:The titled medicine that contains a novel prostaglandin analog as an active ingredient, thus showing strong activity of uterus muscle contraction, abortion, corpus luteum contraction and ovule nidation inhibition. CONSTITUTION:The objective agent contains a prostaglandin analog of the formula[B is O, S; R1, R2 are H, halogen, CF3, 1-4C straight or branched chain, alkoxy; R is COOR3 (R3 is H, 1-12C straight or branched alkyl); wave lines shows alpha- or beta-configuration or their mixture; the configuraton of the 2-3 bond is trans; 5-6 bond is cis; 13-14 bond is trans], its clathrate with cyclodextrin, hor nontoxic salt, when R3 is H. They have especially strong activity of stimulating uterus smooth muscles, abortion and inhibiting ovule nidation among various kinds of activities of prostaglandins, so are used as a medicine for menses induction, birth induction, contraception, and fertility increase.