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Substituted urea and thiourea compounds antiatherosclerotic WITH ACTIVITY; PROCESS FOR THE PREPARATION THEREOF; PHARMACEUTICAL PREPARATIONS having antiatherosclerotic ACTIVITY; METHOD FOR THE TREATMENT OF ATHEROSCLEROSIS.
Substituted urea and thiourea compounds antiatherosclerotic WITH ACTIVITY; PROCESS FOR THE PREPARATION THEREOF; PHARMACEUTICAL PREPARATIONS having antiatherosclerotic ACTIVITY; METHOD FOR THE TREATMENT OF ATHEROSCLEROSIS.
Substituted ureas and thioureas of the formula below are disclosed which are useful as antiatherosclerotic agents IMAGE wherein X represents at least one substituent selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 alkynyl, hydroxy, C1-C4 alkoxy, phenoxy, mercapto, C1-C4 alkylthio, amino, C1-C4 alkylamino, di-(C1-C4 alkyl)amino, halo, trihalomethyl, C1-C4 alkanoyl, benzoyl, C1-C4 alkanamido, C1-C4 alkanesulfonyl, C1-C4 alkanesulfinyl, benzenesulfonyl, toluenesulfonyl, nitro, cyano, carboxy, C1-C4 carboalkoxy, carbamoyl, sulfamyl, methylenedioxy, phenyl, ortho-phenylene, tolyl, benzyl, halobenzyl, methylbenzyl, and the group: IMAGE wherein Y is selected from the group consisting of oxygen and sulfur; R1 and R2 are the same or different and are independently selected from the group consisting of C4-C12 alkyl, C4-C12 alkenyl, C4-C12 alkynyl, C4-C12 cycloalkyl, C4-C12 cycloalkylalkyl, C7-C14 aralkyl, furyl and C7-C14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C1-C10 alkyl, C1-C10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C1- C4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C1-C4 carboalkoxy, and nitro; and R3 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 alkynyl, benzyl, benzyl bearing at least one substituent Z, naphthyl, phenyl, and phenyl bearing at least one substituent Z, Z being selected independently of X from the group consisting of those from which X is selected.
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