Vasodilator di:hydro-pyridine fast-release solid formulations - with good content uniformity contg. active ingredient and PVP granulated with an absorbent carrier

摘要

New solid, fast-release preparations of dihydropyridines (e.g. nifedipin) having good absorption properties and a maximum relative standard deviation of the active substance content of 3% contain (A) 1 wt. part dihydropyridine; (B) 2.0-6.0 wt. parts polyvinyl-pyrrolidone (PVP) of mean molecular weight 15,000-50,000; (C) 3.5-15 wt. parts cellulose, 0.25-4.0 wt. parts starch and 0.25-4.0 wt. parts crosslinked insoluble PVPP as absorbent carrier substance; and, optionally, (D) further usual adjuvants and carriers. Dihydropyridines such as nifedipin and nimodepin have circulatory effects. Nimodepin has cerebral effects. Active substance is absorbed very rapidly and completely, and content uniformity is good.