Lipid lowering agents (血 中 脂質 低下 劑) as novel oxy-acetic acid derivatives, their preparation and active ingredients it

摘要

I (R1 = H, halogen, OH, alkyl, alkoxy; X = halo; n = 1,2; R2 = H, Ph, alkoxycarbonyl, alkyl, hexadodesyl, cyclohexyl, -4- (4-chlorobenzeaminoethyl)-phenoxy--cyclohexylacetoxy-cyclohexy) was prepared from the reaction of II and III. Thus, II was treated with EtONa followed by the addition of -halogeno-cyclohexylacetic ester to give oxyacetic acid derivatives. The solvents of this reaction can be used non-functional organic solvents, such as dimethylformamido and acetone in a reactive condition.