A synergistic mixture of (i) a defoliating and/or growth-regulating compound selected from 1,2,3- thiadiazol-5-yl-urea derivatives and 1,2,3-thiadiazolin-2-ide derivatives with (ii) a basically reactive substance is used for defoliating and/or regulating the growth of plants, preferably cotton plants. Preparations suitable for such use comprise the aforesaid constituents, the ratio by weight of the defoliating and/or growth-regulating compound to the basically reactive substance preferably being 1:0.5 to 1:1000. The defoliating and/or growth- regulating compound is, for example, 1-phenyl-3-(1,2,3-thiadiazol-5-yl)- urea and the basically reactive substance is, for example, an alkali hydroxide, amine, carbonate, phosphate or alkali salt of a monocarboxylic acid.
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