The method of benzoate-Tropez Phil and Phil alkyl pseudo-Tropez

摘要

Title compds. (I)[Ar=(a) or (b) ; n=0,1,3; R1=C1-4 alkyl; R2=C1-4 alkyl, halo, C1-4 alkoxy; R1=R2 if n=2 or 3; R3, R4=H, C1-4 alkyl, alkoxy, halo; R3=alkyl and R4=H in case of tropyl derivs. , useful for hemicrania, were prepd.. Thus, a mixt. contg. 1.76g tropine.HCl and 1.65g 3,4-dimethyl benzoyl chloride was boiled at 130-140C for 30 min to give tropyl 3, 4-dimethyl benzoate (m.p.=270-271C).