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A method for the production of biological compositions for the use as a reference - control samples in the case of the diagnostic analysis
A method for the production of biological compositions for the use as a reference - control samples in the case of the diagnostic analysis
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机译:诊断分析情况下用作参考对照样品的生物学成分的生产方法。
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摘要
The present disclosure is directed to the preparation of stable aqueous-containing biological compositions capable of use as liquid reference serums in diagnostic chemical analysis using multichannel automated analyzers and having improved storage stability and capable of storage in the liquid state for extended periods of time measured in weeks when stored at 2° to 8° C.; processes for preparing the reference serums and the process of automated analysis utilizing the improved reference serums. The subject materials are prepared by freezing the aqueous-containing labile biologicals rapidly at temperatures ranging from about -20° to about -30° C., removing from about 98 to 99 weight percent of the water therefrom and storing same (as a dehydrated solid) at 2° to 8° C. until desired use. The dehydrated material is then reconstituted by dissolving it in a medium containing from about 20 to about 50 wt. % of an alkylene polyol containing from 2 to 5 carbon atoms with the remainder being water. The thus reconstituted biological compositions can be stored in the liquid state at 2° to 8° C. for periods of 4 to 5 weeks or at -20. degree. C. for months.
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