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PROCESS FOR THE CONVERSION OF BECLOMETHASONE 17,21-DI-PROPIONATE THE CRYSTALS WHEREOF ARE LIABLE TO GROWTH IN AN AEROSOL PROPELLENT INTO A FROM SHOWING NO SUCH GROWTH TENDENCY
PROCESS FOR THE CONVERSION OF BECLOMETHASONE 17,21-DI-PROPIONATE THE CRYSTALS WHEREOF ARE LIABLE TO GROWTH IN AN AEROSOL PROPELLENT INTO A FROM SHOWING NO SUCH GROWTH TENDENCY
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机译:没药生长趋势容易使气溶胶推进剂中的17,21-二丙酸倍他米酮转化为晶体的过程
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摘要
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after removal of some or all of the propellant from the crystals, is reduced to a particle size permitting inhalation into the human bronchial system when dispersed as an aerosol, the micronised crystalline solvate not thereafter exhibiting crystal growth in the aerosol propellant. The solvate is a new composition of matter which has been characterized by I.R. spectra and the aerosol formulation prepared therefrom has valuable therapeutic properties, particularly in the treatment of asthma.
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