New 5 - phenyl - 1,3,4,5 - tetrahydro - 2h - 1,4 - benzodiazepin - 2 - one is containing, in the positions 3 and 5 of the centers of the absolute configuration asymmetry a similar process for their preparation and their application of international application no.

摘要

Optically active and racemic 5- phenyl-1,3,4,5-tetrahydro-2H-1,4- benzodiazepin-2-one compounds of general formula (I IMAGE in which the centres of asymmetry in the 3- and 5-positions have the same absolute configuration [wherein R1 represents a hydrogen or halogen atom or a trifluoromethyl or nitro group; R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; R3 represents a group selected from those groups conventionally attached to the -CH(NH2)-COOH group of the optically active or racemic alpha - amino-acids; R4 represents a hydrogen atom or a chlorocarbonyl or carbamoyl group; and X represents a hydrogen or halogen atom or a trifluoromethyl group; with the proviso that if in the racemic compounds R4 represents a hydrogen atom then R3 represents other than an alkyl group having 1 to 6 carbon atoms] and acid addition salts thereof show enzyme inducing activity.