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procedure for the manufacture of a solid form for oral anvendelsebaseret on nifedipine with regulated removal of the active substance
procedure for the manufacture of a solid form for oral anvendelsebaseret on nifedipine with regulated removal of the active substance
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机译:硝苯地平上口服复方安非他塞碱固体制剂的制备方法,其中活性物质的调节去除
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摘要
Process for preparation of a solid administration form for oral use based on nifedipine with controlled release of the active substance, characterized by the fact that a mixture of nifedipine crystals having a specific surface area between 0.1 and 0.4 m2/g is prepared, said mixture of crystals is blended with an equal amount by weight of auxiliary vehicle substances, and the resulting mixture so obtained is applied on spheroids of inert substances, by means of suitable binders, in coating pans.
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