COMBINED HAEMOPHILUS INFLUENZAE AND DIPHTHERIA, PERTUSSIS, TETANUS VACCINE

摘要

COMBINED HAEMOPHILUS INFLUENZAE ANDDIPHTHERIA, PERTUSSIS, TETANUS VACCINEABSTRACTA vaccine for eliciting polyribosyl ribitolphosphate (PRP) antibody formation in a warm-bloodedanimal has been invented. The vaccine comprisesthe capsular polysaccharide PRP isolated and purifiedfrom Haemophilus influenzae type b combined with adiphtheria, Bordetella pertussis and tetanus (DPT) vaccine.A method of making a vaccine for elicitingpolyribosylribitol phosphate (PRP) antibody formation ina warm-blooded animal has also been invented. Themethod of making comprises obtaining purified PRP;dissolving the PRP in phosphate buffered saline solutionhaving a pH of about 7.0; sterile filtering the PRPsolution; and combining the PRP solution with a diphtheria,B. pertussis and tetanus (DPT) vaccine.Finally, a method for inducing active immuniza-tion in a warm-blooded animal against systemic infectioncaused by the pathogen H. influenzae type b has been in-vented. The method of using comprises administering animmunogenic amount of a vaccine comprising the capsularpolysaccharide polyribosyl ribitol phosphate (PRP) iso-lated and purified from H. influenzae type b combinedwith a diphtheria, B. pertussis and tetanus (DPT) vaccine.