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MANUFACTURE OF ANTIHEMOPHILIC FACTOR FOR IMPROVING DISSOLUTION OF COLD-SEDIMENTED AND COLLECTED ANTIHEMOPHILIC FACTOR PRODUCT
MANUFACTURE OF ANTIHEMOPHILIC FACTOR FOR IMPROVING DISSOLUTION OF COLD-SEDIMENTED AND COLLECTED ANTIHEMOPHILIC FACTOR PRODUCT
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机译:制造抗血友病因子以改善冷沉淀和收集的抗血友病因子产品的溶解度
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摘要
An improved method of recovering antihemophilic factor (AHF) from cryoprecipitated blood plasma is provided. The improved method incorporates the addition of a calcium ion source during the step of cold precipitation of fibrinogen and fibronectin contaminants, as well as the addition of polyethylene glycol (PEG) at one of various stages of the recovery process. PEG may be added during the cold precipitation of fibrinogen and fibronectin, during the precipitation of AHF, or prior to the filtration of AHF solution. The method of the present invention results in a final AHF product having greatly increased solubility, higher specific activity, and lower fibrinogen and fibronectin content.
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