A process for preparing heterocyclic compounds fused with benzene

摘要

This invention provides a benzene-fused heterocyclic compound of the formula: IMAGE (I) wherein R1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino, X is -S-, IMAGE n is an integer of 1 or 2 and A is a group of the formula: IMAGE in which R2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.