Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists

摘要

A potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a long-acting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: IMAGE wherein R is methyl, cyclopropylmethyl or allyl, and R1 is an unsubstituted or substituted aryl, aralkyl, heteroaryl, heteroaralkyl or a cycloalkyl group with or without a heteroatom like S,O,N; and the pharmaceutically acceptable salts thereof.