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Demonstration plant for production of hirudin variant in yeast containing plasmid as transformed yeast cell and method for production of hirudin variant by yeast cell
Demonstration plant for production of hirudin variant in yeast containing plasmid as transformed yeast cell and method for production of hirudin variant by yeast cell
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机译:在含有质粒的酵母中生产水rud素变体的示范工厂,以及通过酵母细胞生产水rud素变体的方法
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摘要
Functional DNA block permitting the preparation of hirudine from yeast, characterised in that it comprises at least the sequence: -Str-Lex-Scl-gene H gene H being the hirudine gene or one of its variants, Str is a DNA sequence containing the signals ensuring the transcription of gene H by the yeast, Lex is a leader sequence needed to obtain the excretion of the product of the gene, Scl is a DNA sequence coding for the site of cleavage by the proteinase ycsF, a cleavage site which is unique and situated in the precursor of hirudine immediately ahead of gene H. The invention relates more particularly to a functional DNA block in which gene H codes for HV1.
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