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Bicyclic aromatic derivatives, their process of preparation and suutilizacion in human and veterinary medicine and in cosmetics.

机译:人和兽药以及化妆品中的双环芳族衍生物及其制备和实用化方法。

摘要

COMPOUNDS bicyclic aromatic, of formula (I) wherein n is 0 or 1; R 'represents H, OH, C1-C4alkoxy or acyloxy C1-C4 alkyl; R "represents C1-C4 alkoxy HO O R '' YR" OXO A taken together form (= O), methane (= CH2) O HIDRIXIIMINO (= N-OH) radical; R represents -CH2OH or -COR7; H REPRESENTING R7, -OR8 or (II); R8 REPRESENTING H, C1-C20 alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl group optionally substituted or a radical E sugar or TODAINA RADICAL - (CH2) PN (III), p being 1, 2 or 3 and R '' YR "REPRESENTING H, lower alkyl, monohydroxyalkyl optionally interrupted by a heteroatom polyhydroxyalkyl, aryl or benzyl, optionally substituted (S), A amino acid residue or SUGAR aminated or taken together form with the nitrogen atom to which they are related, it a heterocycle, A methylene or dimethylene, substituted or represents lower alkyl, R1, R2, R3 and R4 represent H, lower alkyl; R1 and R3 taken together may form a methylene radical or dimethylene, when A represents a dimethylene radical, R5 and R6 represent HO methyl, and salts of these compounds, their isomers optical and geometric. USE AS ACTIVE cOMPOUND IN THE FIELD pharmaceutical or cosmetic.
机译:式(I)的化合物双环芳族化合物,其中n为0或1; R'代表H,OH,C1-C4烷氧基或酰氧基C1-C4烷基; R“代表C 1 -C 4烷氧基HO O R” YR” OXO A一起以(= O),甲烷(= CH 2),HIDRIXIIMINO(= N-OH)基团形式存在; R代表-CH 2 OH或-COR 7; H代表R7,-OR8或(II); R8代表H,C1-C20烷基,单取代的烷基,多羟基烷基,芳基或芳烷基,其任选被取代或基团E糖或TODAINA RADICAL-(CH2)PN(III),p为1、2或3,且R” YR”代表H,低级烷基,任选被杂原子多羟基烷基,芳基或苄基间断的单羟基烷基,任选取代的(S),与它们相关的氮原子胺化或一起形成的氨基酸残基或糖,其为杂环,亚甲基或被取代或代表低级烷基的二亚甲基,R1,R2,R3和R4代表H,低级烷基;当A代表二亚甲基,R5和R6代表HO甲基时,R1和R3一起可形成亚甲基或二亚甲基。这些化合物的盐,它们的异构体是光学的和几何的,在药物或化妆品中用作活性化合物。

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