Novel purified plasminogen activator, process for its production and thrombolytic composition containing it

摘要

A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties: (a) molecular weight measured by gel filtration: 63,000+/-10,000, (b) isoelectric point: 7.0-8.5, (c) affinity to fibrin: present, (d) affinity to concanavalin A: present, (e) optimum pH: 7-9.5, and (f) stability: does not lose activity at 60 DEG C. for 10 hours but loses about 5% of activity at pH 2-3 at 98 DEG C. for a minute; a process for the production of the aforesaid plasminogen activator; and a thrombolytic composition containing the aforesaid plasminogen activator as an active ingredient are disclosed.