(2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl)-oxyethanimidamides and (2,3,9,9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7yl)oxyethanimidic acid hydrazides, their derivatives and their salts

摘要

The invention relates to novel compounds of the formula:wherein:R is, e.g., alkyl containing from I to 5 carbon atoms;R' is NH,, NHR' or NR³R⁴;R² is NH or NR³;R', R⁴ are,e.g., alkyl containing from I to 5 carbon atoms, or amino, provided that R³ and R⁴ are not both amino;wherein R' and R² may be joined together via R³ to form a heterocyclic ring of 5 or 6 atoms containing 2 nitrogen atoms and 3 or 4 carbon atoms; or wherein R³ and R⁴ may be joined together to form a 5-or 6-membered ring containing one nitrogen atom, and 4 or 5 carbon atoms; andX and Y are halo or lower alkyl, such as methyl; or the pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and prevention of injury to the brain and of edema.