SUPPORTS, THE PREPARATION OF THESE SUPPORTS, INTERMEDIATES OBTAINED, THEIR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES, AND NUCLEOSIDES AND OLIGONUCLEOTIDES LINKED TO THE SUPPORTS

摘要

Novel supports useful in solid phase synthesis of oligonucleotides of the formula IMAGE I +TR IMAGE wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.