CACHEXIA-IMPROVING REMIDY

摘要

PURPOSE:To provide the subject remedy capable of decomposing triglycerides contained in ultralow density lipoprotein is blood and chylomicron to metabolize neutral fats to be stored, by containing a specific pyrimidine derivative (salt) as an active ingrediate. CONSTITUTION:The objective tready contains as an active ingredient a pyrimidine (salt) of formula I [Y is formula II or III (R2 is H or halogen); R1 is H, lower alkyl or aryl; R3 is lower alkyl or cyloalkyl; R4 is H, lower alkyl, OH or halogen (but when Y is formula III and the dotted line exhibits a double band); R5 is H, lower alkyl, OH, oxo or halogen (but when Y is formula III and the dotted line exhibits a double bond); R6 is H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl; the dotted line is a single bond or double band]. The pyrimidine of formula I is usually administered in a dose of 10-1000mg/day orally and in a dose of 10-500mg/time parenterally.