New origodeokishinukureochido, the method of blocking the revelation of the target gene which uses that, and of obstructing new origodeokishinukureochido and the revelation of the target gene which uses that the method

摘要

The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.