Chromatographic adsorbent particles (10) having covalently bound at least one active substance for binding molecules in a liquid chromatographic fluid bed process; said adsorbent particles being constituted by a porous composite material having pores allowing access to the interior of the composite material of said molecules; wherein the porous composite material consists of a conglomerate having controlled relative density; said conglomerate consisting of: (i) at least two density controlling basic particles (11) of amorphous silica, quartz, or glass; and (ii) a matrix formed by consolidating at least one conglomerating agent (12) selected from the group consisting of natural and synthetic polysaccharides and other carbohydrate based polymers with the proviso that the conglomerating agent is not beta -1,3-glucan. The at least two density controlling basic particles are dispersed in said matrix; the size range of the adsorbent particles is controlled; said density and said size range are selected to provide desired floatation/sedimentation properties of said adsorbent particles in the liquid in said fluid bed process; and the at least one active substance is covalently bound to said matrix. Methods of preparing such adsorbent paticles, their use as a solid phase matrix in a fluid bed reactor, and particularly their use for distributing the liquid in the fluid bed of such a reactor. IMAGE
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机译: (54)标题:具有硅酸盐涂层的固体颗粒(54):FESTKoRPERPARTKEL MIT SILKATBESCHICHTUNG(57)摘要:本发明涉及一种具有二氧化硅涂层的固体颗粒的生产方法,其包括以下步骤:将固体颗粒分散为将其涂覆在水性介质中以产生固体颗粒分散体,通过缓冲系统调节固体颗粒分散体的pH以产生缓冲的固体颗粒分散体,并向缓冲的固体颗粒分散体中添加碱性硅酸盐溶液以形成二氧化硅在涂覆期间将其涂覆在固体颗粒上,其中选择缓冲体系和碱性硅酸盐溶液的量,使得在添加碱性硅酸盐溶液之前和在添加完成之后,缓冲的固体颗粒分散体的pH至少为7.0。碱性硅酸盐溶液的最大含量为11.0。固体颗粒优选是无机固体,特别是