Method to preserve eye barrier and use of preserved eye barrier

摘要

Method of pressing an ophthalmic soln. comprises adding a source of a germicidally effective amt. of H2O2 and an effective amt. of H2O2-stabiliser. Pref. amt. of H2O2 produced is 0.001-0.10 wt.%, and this is the only preservative used. The H2O2 source is H2O2, sodium perborate decahydrate, sodium peroxide or urea peroxide. The stabiliser is 0.002-0.03 wt.% of diethylenetriamine penta (methylenephosphonic acid) or 0.005-0.2 wt.% of 1-hydroxyethylidene-1,1-diphosphonic acid, or their physiologically compatible salts. The soln. may also comprise 0.003-0.1 wt.% glycerin, and/or a toxicity agent: (buffers, NaCl, etc.) and/or an ophthalmically acceptable active ingredient which is comptabile with H2O2. Usual ophthalmic drugs may be used, provided they are H2O2-comptible. Amt. of H2O2 is reduced to less than 100 ppm, less than 60 ppm before contact with the eye.