Method of, and apparatus for, NMR spectroscopic metabolite imaging and quantification

摘要

A method for NMR spectroscopy metabolite imaging utilizes the steps of: applying to a desired portion of a sample a pulsed phase-encoding linear magnetic gradient signal in at least one of the three orthogonal dimensions of a Cartesian coordinate set, prior to acquisition of free-­induction-decay NMR response signals from the sample por­tion; substantially eliminating from at least the sample portion eddy current fields induced responsive to the phase-encoding gradient pulses; maximizing the signal-to-­noise ratio of the NMR response signals; and displaying the data resulting from Fourier transformation of the received response data. A high-field imaging system is provided with self-shielded gradient coils, to substantially remove eddy-current effects, and at least one of maximized-SNR antenna, of quadrature-driven volume RF coil and/or surface RF coil types are utilized for both transmission of the excitation RF pulses and reception of the RF response signals. The acquired FID data is filtered and a Fourier transform reconstruction, of dimension d′ equal to one greater than the number d of spatial dimensions to be displayed, is performed.