RECOMBINANT DNA MOLECULE ENCODING AT LEAST ONE POLYPEPTIDE DISPLAYING THE IMMUNOGENICITY OF AT LEAST ONE MEROZOITE ANTIGEN OR ASEXUAL BLOOD STAGE ANTIGEN OF P.FALCIPARUM,VECTORS COMPRISING THE DNA MOLECULE,HOST CELLS TRANSFORMED THEREBY,IMMUNOGENIC POLYPEPTIDES PRODUCED BY HOST CELLS AND COMPOSITIONS CONTAINING THE POLYPEPTIDES

摘要

DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of Plasmodium falciparum messenger RNA (mRNA) or genomic DNA (gDNA). Especially DNA molecules comprising artificially constructed polynucleotide sequences coding for the whole or part of one or more proteins occuring in P. falciparum, or a precursor or modification thereof. Such DNA molecules are capable of being expressed as a polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of at least one P. falciparum antigen. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of a P. falciparum antigen, together with a pharmaceutically acceptable carrier therefor.