HGM-CSF HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR AND VECTOR FOR ITS EXPRESSION CONTAINING THE SR#A# PROMOTER OF THE PLASMID DEPOSITED IN ATCC67318

摘要

Human granulocyte-macrophage colony stimulating factor (GM-CSF) polypeptides are provided, as well as methods for synthesizing conformationally and antigenically neutral muteins. The disclosed GM-CSFs promote growth and development of various hematopoietic lineages, and may be useful in treating conditions involving depressed blood cell populations and/or depressed blood cell regeneration, such as myeloid hypoplasia, chronic infections, and hematopoiesis after bone marrow transplantation. The invention also includes a novel mammalian expression vector.