2-Guanidino-4-arylthiazoles for treatment of peptic ulcers

摘要

2-Guanidino-4-arylthiazole compounds of the formula CHEM a pharmaceutically acceptable cationic or acid addition salt thereof wherein R1 is hydrogen, (C1-C10)alkyl, optionally substituted phenyl or certain optionally substituted aralkyl groups; R2 is hydrogen or (C1-C4)alkyl, and Ar is certain optionally substituted pyrrolyl or indolyl groups; method for their use in treatment of gastric ulcers, by inhibition of parietal cell H+/K+ ATPase, and antiinflammatory conditions in combination with piroxicam, for use in mammals, and pharmaceutical compositions containing said compounds.