Platinum complexes with one radiosensitizing ligand

摘要

Methods to inhibit tumor growth and to radiosensitize hypoxic cells and pharmaceutical compositions therefor are disclosed. These methods and compositions use compounds of the formulaPP PtX.sub.n (NR. sub.2 H) (L) (1)PPwherein n is 1 or 2, andP Pwherein when n is 2, X is a monovalent biologically acceptable anion, and when n is 1, X is a divalent biologically acceptable anion;P Peach R is independently H or alkyl, or both Rs together are a piperidino or morpholino residue; andP PL is a radiosensitizing ligand selected from a mononitro- substituted imidazole, a mononitro-substituted pyrazole, a mononitro- substituted thiazole and a mononitro-substituted isothiazole.