VILLIN GENE PROMOTER SEQUENCE AND ITS USE IN VECTORS, TRANSFORMED MAMMALIAN CELL LINES, TRANSGENIC ANIMALS, AND CELL LINES DERIVED FROM THE ANIMALS

摘要

VILLIN GENE PROMOTER SEQUENCE AND ITS USE IN VECTORS, TRANSFORMED MAMMALIAN CELL LINES, TRANSGENIC ANIMALS, AND CELL LINES DERIVED FROM THE ANIMALS An isolated DNA sequence encoding a promoter of the human villin gene is provided. The DNA sequence can be operatively linked to a nucleotide sequence of a gene, such as an oncogene, and incorporated in cloning and expression vectors. The vectors are useful in the production of transgenic, non-human mammals as models of colorectal cancer.