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3 - (so it is methyl) - 5, 5 - two benzene of the pagan natives is the sodium salt of the ester of the stability of a medicament of water science
3 - (so it is methyl) - 5, 5 - two benzene of the pagan natives is the sodium salt of the ester of the stability of a medicament of water science
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机译:3-(所以是甲基)-5、5-异教徒本地人的两个苯是水科学稳定药物酯的钠盐
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摘要
Described is a stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester, the produg of 5,5-diphenylhydantoin (phenytoin) a commonly used drug for the treatment and management of epilepsy and other types of convulsive states. It has been found that degradation of the produg to phenytoin can be controlled by controlling the pH of the composition. Controlling the pH to between 8.3 to 9.4 results in the production of diphenylglycinamide as the primary degradant and minimization of degradation to phenytoin. If the pH is maintained at a lower or higher value, then the degradation pattern changes, with earlier than expected product failure.
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