FOERFARANDE Før FRAMSTAELLNING audio NYA TERAPEUTISKT ANVAENDBARA 1- / 3- (2-AMINOETOXI) -2-thienyl / 3-PHENYL-1-PROPANONER

摘要

Therapeutically useful 1-[3-(2-dialkylaminoethoxy)-2-thienyl]-3-phenyl-1-propanones of the formula IMAGE (I) and acid addition salts thereof, wherein R and R1 each are hydrogen or methyl, R2 and R3, which are the same or different, each are alkyl, cycloalkyl, alkenyl or alkynyl each containing up to 8 carbon atoms, or R2 and R3 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated ring or a saturated heterocyclic ring which may contain optionally an oxygen or nitrogen atom as further hetero atom in the ring, a further nitrogen atom being unsubstituted or substituted by an alkyl radical containing 1 to 3 carbon atoms. The compounds are useful for the treatment of various disturbances of the heart rhythm.