CONJUGATES OF THE CLASS II PROTEIN OF THE OUTER MEMBRANE OF NEISSERIA MENINGITIDIS AND OF HIV-1 RELATED PEPTIDES, AND VACCINES CONTAINING SAME

摘要

104/GHB24 122/GHB35 18441 TITLE OF THE INVENTION CONJUGATES OF THE CLASS II PROTEIN OF THE OUTER MEMBRANE OF NEISSERIA MENINGITIDIS AND OF HIV-1 RELATED PEPTIDES, AND VACCINES CONTAINING SAME The Class II major immuno-enhancing protein (MIEP) of Neisseria meningitidis, purified directly from the outer membrane of Neisseria meningitidis, or obtained through recombinant cloning and expression of DNA encoding the MIEP of Neisseria meningitidis, has immunologic carrier as well as immunologic enhancement and mitogenic properties. Conjugates of this protein and HIV-1 related peptides are useful for the induction of mammalian immune responses directet against the peptides, against HIV-1 strains, and for the neutralization of HIV-1 and prevention of HIV-I related diseases.