Antiinflammatory and immunosuppressant triheterocyclic FK506-like compounds and processes for their preparation

摘要

The compounds of formula I CHEM wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity. They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N min -carbonyl- or N,N min -thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane or -ethane, optionally under transient protection of reactive groups which it is not desired to react.