POTENTIAL TARGET FOR IMMUNOTHERAPY TO PREVENT REPLICATION OF HIV (AIDS VIRUS) IN HUMANS: CDNA AND PROTEIN FOR A PUTATIVE REGULATOR OF HIV GAG POLYPROTEIN EXPRESSION RECONSTRUCTED FROM THE ANTISENSE STRAND OF HUMAN P53 GENE

摘要

A cDNA reconstructed from the antisense strand of human p53 gene encodes a 53 aa nuclear protein (Higaa) which has the potential for interacting with a domain of very highly conserved sequences in HIV gag polyprotein precursor. The protein which appears to be an intracellular activator of gag may be important for the successful replication of HIV in human cells. Since the protein is constitutively repressed by the p53 gene in normal cells, it is potentially a good target for a simple immunological approach to prevent multiplication of HIV following integration of the viral genome into the human genome.