Pharmaceutical preparations containing neurotrophic factors and gangliosides for treating nervous system pathologies

摘要

Provided is a pharmaceutical composition comprising at least one neurotrophic factor such as ciliary neurotrophic factor at a sub-threshold concentration ineffective in treating excitatory amino acid-induced neurotoxicity, and at least one ganglioside, ganglioside derivative, semisynthetic ganglioside analogue, or salt thereof such as GM1 or AGF2 at a sub-threshold concentration ineffective in treating excitatory amino acid-induced neurotoxicity. Such compositions can be prepared in the form of delivery vehicles such as microspheres, microcapsules, sponges, tubes, and guide channels comprising hyaluronic acid esters. These pharmaceutical compositions can be used in human and veterinary medicine to treat excitatory amino acid-induced neurotoxicity.