NUCLEIC ACID ENCODING INSULIN RECEPTOR SUBSTRATE-1 (IRS-1), IRS-1 PROTEIN, DISEASES, THERAPY ASSOCIATED WITH THE METABOLISM OF IRS-1

摘要

The invention relates to a purified nucleic acid consisting essentially of nucleic acid encoding the insulin substrate-1 receptor (IRS-1); to a purified polypeptide preparation of IRS; the diagnosis of diseases associated with insulin consist of measuring an aspect of the metabolism of the IRS-1; diagnosing a disease associated with insulin observed in a patient, which includes determining the structure of the IRS-1 gene; to analyze the effect of a therapeutic agent that alters the ability of a tyrosine kinase to phosphorylate a substrate such as; to an application of a treatment in a mammal suffering from a disease caused by the metabolism of the IRS-1; and applying a treatment for a mammal suffering from a disease caused by the phosphorylation of a substrate of a tyrosine kinase.