Tylosin and 10,11,12,13-tetrahydrotylosin derivatives, processes for their preparation and their use in pharmaceutical compositions and in their production.

摘要

Derivatives of tylosin and 10,11,12,13-tetrahydro tylosin of the general formula CHEM wherein R stands for CHO, CH2OH CH=NOH or CH(OCH3)2, R1 stands for H, R2 stands for OH or R1 + R2 stand for =O or =NOH, R3 stands for a mycarosyl group or a hydrogen atom, and @ @@ stands for a single or a double bond; methods for the manufacture thereof; their use as antimicrobial agents and processes for the preparation of the latter.