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Manufacture of vitamin d2 and vitamin d3 or active vitamin d2 and active vitamin d3 or their derivatives.
Manufacture of vitamin d2 and vitamin d3 or active vitamin d2 and active vitamin d3 or their derivatives.
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机译:生产维生素d2和维生素d3或活性维生素d2和活性维生素d3或其衍生物。
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摘要
PURPOSE:To practically obtain vitamin Ds through simplified processes in high yield by reductive elimination reaction of 7,8-dihydroxyvitamin D2 through a cyclic orthoester in the 7,8-dihydroxy groups. CONSTITUTION:A compound of formula I (R is H, dotted line is C-C bond, R is methyl, dotted line represents additional bond (for example double bond; R1-R3 are H, hydroxyl protecting group; X, Y are H, hydroxyl and its derivative) is subjected to reductive elimination reaction passing through 7,8-dihydroxy cyclic orthoester or its homologue and thionocarbonate, or elimination reaction of the 7,8-dihydroxy derivative with a metal such as reduced titanium to produce vitamin D2 and D3 or active form of vitamim D2, D3 or their derivatives.
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