Isolated, large latent complexes of TGF-2 and TGF-3, and new binding protein for latent form TGF-1, TGF-2 and TGF- 3 LTBP-2

摘要

The invention relates to large latent complexes of TGF-2 and TGF- 3, and methods for isolating these. The complex consists of a dimerized form of TGF-2 or TGF-3, the appropriate latency associated peptide, and the latent TGF-1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-1, TGF-2 and TGF-3, but is immunologically distinct from LTBP, referred to as LTBP-2.