PURPOSE:To obtain an extract solution of Perilla frutescens Britton var. acuta Kudo, capable of specifically suppressing the production of a tumor necrosis factor (TNF), greatly effective against allergic diseases such as atopic dermatitis and usable in the form of an antiallergic food, a healthy food, a cosmetic, a quasi-drug, etc. CONSTITUTION:This extract solution is obtained by removing perillaldehyde and a fraction having =1000 molecular weight from ingredients prepared by grinding a stem and a leaf of a plant of the family Labiatae and extracting the resultant ground stem and leaf with water, an organic solvent or a mixture solution thereof. The extract solution has suppressing actions on the production of a TNF.
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